Mots-C

Amino Acid Sequence:

Met‑Arg‑Trp‑Gln‑Glu‑Met‑Gly‑Tyr‑Ile‑Phe‑Tyr‑Pro‑Arg‑Lys‑Leu‑Arg

Chemical Formula:

C₁₀₁H₁₅₂N₂₈O₂₂S₂

CAS Registry Number:

1627580‑64‑6

Metabolic regulation (insulin sensitivity, glucose control)
Fat oxidation & mitochondrial efficiency
Exercise performance & endurance
Anti‑inflammatory and cytoprotective effects
Healthy aging & longevity research
Stress‑response modulation via AMPK activation
Obesity, metabolic syndrome, and type 2 diabetes

Mitochondrial Signaling & Gene Regulation

Encoded in mitochondrial DNA (12S rRNA gene)
Translocates to the nucleus under stress
Regulates genes involved in metabolism, inflammation, and longevity

Metabolic Regulation

Activates AMPK, enhancing metabolic flexibility
Improves insulin sensitivity and glucose control
Promotes fat oxidation and mitochondrial efficiency

Stress‑Response & Cytoprotection

Protects cells from metabolic and inflammatory stress
Supports cellular homeostasis during aging and metabolic dysfunction
Enhances resilience to oxidative and inflammatory damage

MOTS‑c is an experimental research peptide and is not FDA‑approved. Current evidence comes from preclinical studies and early‑stage human research. Despite its investigational status, MOTS‑c has generated significant interest in longevity, metabolic‑health, and performance‑research communities due to its mitochondrial origin and promising early findings. Its unique role as a mitochondrial‑encoded signaling peptide continues to drive scientific exploration into whole‑body energy regulation.

1. Lee, C., Zeng, J., Drew, B. G., Sallam, T., Martin‑Montalvo, A., Wan, J., Kim, S. J., Mehta, H., Hevener, A. L., & Cohen, P. (2015). The mitochondrial‑derived peptide MOTS‑c promotes metabolic homeostasis and reduces obesity and insulin resistance. Cell Metabolism, 21(3), 443–454.

2. Reynolds, J. C., Lai, R. W., Woodhead, J. S. T., Joly, J. H., Mitchell, C. J., Cameron‑Smith, D., Lu, R., Cohen, P., & Merry, T. L. (2021). MOTS‑c is an exercise‑induced mitochondrial‑encoded regulator of age‑dependent physical decline and muscle homeostasis. Nature Communications, 12, 470.

3. Kim, S. J., Miller, B., Mehta, H. H., Xiao, J., Wan, J., Arpawong, T. E., Yen, K., & Cohen, P. (2018). The mitochondrial‑encoded peptide MOTS‑c prevents diet‑induced obesity and insulin resistance. Aging, 10(8), 1650–1664.

4. Zarse, K., Ristow, M., & Cohen, P. (2019). Mitochondrial peptides as regulators of metabolism and aging: the role of MOTS‑c. Gerontology, 65(3), 216–222.

5. Lu, H., et al. (2020). MOTS‑c enhances AMPK activation and improves metabolic flexibility under stress. Journal of Molecular Endocrinology, 64(2), 123–134.

6. Miller, B., et al. (2020). Mitochondrial‑derived peptides and their role in metabolic disease: focus on MOTS‑c. Frontiers in Endocrinology, 11, 1–12.*

7. Cohen, P., & Lee, C. (2020). Mitochondrial peptides as novel regulators of metabolism and aging. Annual Review of Physiology, 82, 417–445.*

CURRENT BATCH LOT NUMBER: MS402026-04-07

CERTIFICATE OF ANALYSIS – TGMPURE MOTS-C 40 MG (MS402026-05-04)