KPV

Amino Acid Sequence:

Lys‑Pro‑Val

Chemical Formula:

C₁₆H₃₀N₄O₄

CAS Registry Number:

27251‑22‑5

(Note: KPV is a 3‑amino‑acid peptide; variants such as KdPV or extended analogs may appear in research literature.)

• Anti‑inflammatory modulation

• Gut barrier integrity & mucosal healing

• Skin inflammation & dermatologic research

• Wound healing & tissue repair

• Oxidative‑stress reduction

• Immune‑system balance

• Antimicrobial activity

Anti‑Inflammatory Modulation

• Downregulates pro‑inflammatory cytokines (TNF‑α, IL‑1β, IL‑6)

• Supports anti‑inflammatory pathways via melanocortin receptor signaling

• Reduces oxidative stress and inflammatory cascade activation

Epithelial Barrier Protection

• Enhances tight‑junction integrity in epithelial tissues

• Supports mucosal healing in gut and skin models

• Reduces epithelial permeability under inflammatory stress

Antimicrobial & Cytoprotective Effects

• Exhibits antimicrobial activity against select pathogens

• Protects tissues from inflammatory and oxidative damage

• Supports wound healing and tissue recovery

KPV is an experimental research peptide and is not FDA‑approved for therapeutic use. Current evidence is derived from preclinical studies and early exploratory research. Despite its investigational status, KPV continues to attract interest in inflammation biology, epithelial‑barrier research, and tissue‑healing science due to its potent anti‑inflammatory and cytoprotective profile.

1. Adnan SB, Maarof M, Fauzi MB, Fadilah NIM. Exploring the Role of Tripeptides in Wound Healing and Skin Regeneration: A Comprehensive Review. Int J Med Sci. 2025 Oct 1;22(16):4175-4200. 

2. Land SC. Inhibition of cellular and systemic inflammation cues in human bronchial epithelial cells by melanocortin-related peptides: mechanism of KPV action and a role for MC3R agonists. Int J Physiol Pathophysiol Pharmacol. 2012;4(2):59-73. 

3. Dalmasso G, Charrier-Hisamuddin L, Nguyen HT, Yan Y, Sitaraman S, Merlin D. PepT1-mediated tripeptide KPV uptake reduces intestinal inflammation. Gastroenterology. 2008 Jan;134(1):166-78.

4. Luger TA, Brzoska T. alpha-MSH related peptides: a new class of anti-inflammatory and immunomodulating drugs. Ann Rheum Dis. 2007 Nov;66 Suppl 3(Suppl 3):iii52-5. 

5. Viennois E, Ingersoll SA, Ayyadurai S, Zhao Y, Wang L, Zhang M, Han MK, Garg P, Xiao B, Merlin D. Critical role of PepT1 in promoting colitis-associated cancer and therapeutic benefits of the anti-inflammatory PepT1-mediated tripeptide KPV in a murine model. Cell Mol Gastroenterol Hepatol. 2016 May;2(3):340-357

6. Cheng J, Wu P, Li C, Han Y, Sun M, Dou Y, Chen S, Zhang J. Inflammation-triggered self-immolative conjugates enable oral peptide delivery by overcoming gastrointestinal barriers. Sci Adv. 2026 Jan 16;12

CURRENT BATCH LOT NUMBER: KPV102026-05-04

CERTIFICATE OF ANALYSIS – TGMPURE KPV 10 MG (KPV102026-05-04)