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GHK-cu

SKU CU50 Categories ,

$70.00

Amino Acid Sequence:

Gly‑His‑Lys

Chemical Formula:

C₁₄H₂₂CuN₆O₄

CAS Registry Number:

89030‑95‑5

  • Skin repair & rejuvenation (collagen, elastin, glycosaminoglycans)

  • Wound healing & tissue regeneration

  • Anti‑inflammatory and antioxidant activity

  • Hair growth stimulation via follicular signaling

  • Anti‑fibrotic effects and scar remodeling

  • DNA repair & cellular protection

  • Stem‑cell activation & gene‑expression modulation

Core biological activities observed in research:

Peptide–Metal Complex Function

  • Binds copper(II) to form a bioactive complex

  • Regulates gene expression across hundreds of repair‑related pathways

  • Supports antioxidant and cytoprotective responses

Tissue Remodeling & Repair

  • Stimulates collagen, elastin, and glycosaminoglycan production

  • Enhances extracellular matrix turnover

  • Modulates metalloproteinases (MMPs) and their inhibitors

Cellular Regeneration

  • Activates stem‑cell pathways

  • Improves cellular viability under oxidative or injury stress

  • Promotes angiogenesis and microvascular support

Anti‑Inflammatory Effects

  • Reduces inflammatory cytokines

  • Supports wound‑healing environments

GHK‑Cu is considered safe and widely used in topical and cosmetic applications, including dermatology and hair‑care formulations. However, systemic or injectable use remains experimental, and GHK‑Cu is not FDA‑approved as a therapeutic agent, despite large amount of anecdotal evidence supporting a central role in cellular regeneration and influence in collagen synthesis. Current clinical evidence is primarily derived from in‑vitro studies, animal models, and cosmetic research.

1. Pickart, L., & Thaler, M. M. (1973). Tripeptide in human serum that promotes the uptake of copper by cultured cells. Nature, 243(5405), 85–87.
2. Pickart, L. (2008). The human tri-peptide GHK and tissue remodeling. Journal of Biomaterials Science, Polymer Edition, 19(8), 969–988.
3. Maquart, F. X., Bellon, G., Chaqour, B., Wegrowski, Y., & Monboisse, J. C. (1993). Stimulation of collagen synthesis by the tripeptide‑copper complex GHK‑Cu in fibroblast cultures. Journal of Cellular Physiology, 157(2), 319–327.
4. Siméon, A., Wegrowski, Y., Bontemps, Y., & Maquart, F. X. (2000). Expression of extracellular matrix proteins in wound healing: effects of GHK‑Cu. Journal of Investigative Dermatology, 115(6), 962–968.
5. Pickart, L., Margolina, A., & Vasquez‑Soto, R. (2015). GHK‑Cu and gene expression: modulation of pathways involved in inflammation, antioxidant defense, and tissue repair. BioMed Research International, 2015, 1–12.
6. Al‑Saedi, A., et al. (2019). Copper peptides in dermatology: mechanisms of action and clinical applications. International Journal of Cosmetic Science, 41(5), 411–420.
7. Finkley, M. B., et al. (2009). GHK‑Cu stimulates hair growth and follicular enlargement in human scalp tissue. Journal of Dermatological Treatment, 20(4), 213–218.
8. Pickart, L., & Margolina, A. (2018). GHK‑Cu as a regenerative and protective peptide: implications for aging and chronic disease. Clinical Interventions in Aging, 13, 231–240.

CURRENT BATCH LOT NUMBER: CU502026-02-02

CERTIFICATE OF ANALYSIS – ENDOTOXINS – TGM PURE GHKCU 50 MG (CU502026-02-02)

CERTIFICATE OF ANALYSIS – QUANTITATIVE – TGM PURE GHKCU 50 MG (CU502026-02-02)

full product description

GHK‑Cu (glycyl‑L‑histidyl‑L‑lysine–copper) is a naturally occurring copper‑binding tripeptide first identified in human plasma and later found in saliva and urine. It plays a central role in tissue remodeling, wound repair, anti‑inflammatory signaling, and cellular regeneration. As a bioactive peptide‑metal complex, GHK‑Cu influences gene expression across hundreds of pathways related to collagen synthesis, angiogenesis, antioxidant defense, and anti‑fibrotic activity.

Modern research (2010s–2020s) highlights its ability to activate stem‑cell pathways, enhance extracellular matrix integrity, and modulate metalloproteinases involved in tissue turnover. GHK‑Cu also demonstrates strong anti‑inflammatory and cytoprotective effects, reducing oxidative stress and supporting cellular viability under injury conditions. In dermatology, GHK‑Cu is widely studied for skin rejuvenation, hair follicle stimulation, and scar remodeling. While considered safe in topical and cosmetic applications, GHK‑Cu remains an experimental therapeutic peptide in systemic or injectable contexts.

GHK‑Cu supports tissue regeneration, reduces inflammation, and enhances cellular repair, making it a leading peptide in dermatologic and regenerative‑medicine research. Its broad gene‑modulating effects continue to drive interest in next‑generation therapeutic applications.

QUANTITY: 50 MG

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